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inhalers bretaris genuair and COPD | MyCOPDTeam

inhalers bretaris genuair and COPD | MyCOPDTeam
Does anyone here use Bretaris Genuair 322mcg? I have one puff twice per ... gave up smoking over 12 mths ago not coughed for about 6 months ive stopped taking my spiriva inhaler am i doing right by stopping it. I gave up smoking over ... Is there a gen

QD in the morning; aclidinium administered BID in the morning and evening). Anticholinergic therapies (LAMA, short-acting muscarinic antagonist [SAMA], or short-acting β-2 agonist plus SAMA) had been used by 25. Improvements in nighttime symptom severity were significantly different versus placebo for aclidinium only, which could suggest that the numerical advantage of aclidinium over tiotropium for greater nighttime bronchodilation may translate into statistically significant changes in patient-reported outcomes. Due to the double-blind, double-dummy design of this study, adherence to tiotropium QD compared with aclidinium BID could not be assessed but may be of interest for future work. Poland) were randomized, treated, and included in the study analyses, and 400 completed the study (Figure ).

However, unlike in asthma where variation in lung function and symptoms has been better characterized, the clinical relevance of nighttime symptoms can sometimes be underestimated in COPD and a lack of routine assessment means they can be under-reported ( ), maintaining significant bronchodilation and symptom control over 24 hours should be an important goal of therapy. This Phase IIIb study was designed to evaluate the 24-hour bronchodilatory efficacy of aclidinium 400 μg BID in patients with moderate-to-severe COPD. These are found to 65% in the urine and to 33% in the faeces. Only aclidinium significantly reduced the severity of early-morning cough, wheeze, shortness of breath, and phlegm, and of nighttime symptoms versus placebo (p < 0. Many patients with COPD experience early-morning or nighttime peaks in symptom severity ( ), there is a lack of therapeutic options for their management.

Difference from placebo in change from baseline in (A) severity of early-morning symptoms, (B) severity of nighttime symptoms and number of nocturnal awakenings due to COPD symptoms, and (C) limitation of activity caused by COPD symptoms (COPD additional Over 6 weeks, there was a significant increase in relief medication-free days with aclidinium and tiotropium versus placebo (difference of 9. These findings are consistent with an earlier 15-day Phase IIa cross-over study (n = 30) that also evaluated 24-hour bronchodilation with aclidinium versus placebo and tiotropium, although a larger difference between aclidinium and placebo for the change from baseline in FEV (232 mL) was reported previously, potentially as a result of differences in trial design and duration ( Also consistent with previous findings are the numerically greater improvements in nighttime bronchodilation achieved with aclidinium versus tiotropium in this study, with statistically significant improvements favoring aclidinium on day 1 of treatment. Nasopharyngitis and headache were most common, each reported by 5. Patients with a history or current diagnosis of asthma or other clinically significant respiratory or cardiovascular conditions were excluded, as were those who had experienced any respiratory tract infection or COPD exacerbation ≤6 weeks before screening (≤3 months if exacerbation resulted in hospitalization), or for whom the use of muscarinic antagonists was contraindicated. Nighttime symptom severity was significantly reduced from baseline over 6 weeks with aclidinium versus placebo but not with tiotropium versus placebo (Figure ); the difference between active treatments was not statistically significant. No potentially anticholinergic AEs were serious or led to discontinuation. This provided >90% power to detect a 130 mL difference between aclidinium and placebo for the primary and secondary endpoints, and >80% power to detect a 70 mL difference between aclidinium and tiotropium for the secondary endpoint, with a two-sided significance level of p < 0. The option of ‘no preference’ was chosen by 9. Improvements in individual domain scores were numerically greater with aclidinium than tiotropium, and the improvement for cough and sputum was significant versus placebo for aclidinium only (p < 0. There were no clinically significant physical examination or vital signs findings.

Aclidinium bromide - Wikipedia
Aclidinium bromide (INN) is a long-acting, inhaled muscarinic antagonist (LAMA) approved in the US on July 24, 2012 as a maintenance treatment for chronic obstructive pulmonary disease (COPD). Evidence shows that it can improve quality of life and prev

Jun 22, 2013 ... This randomized, double-blind, Phase IIIb study evaluated the 24-hour bronchodilatory efficacy of aclidinium bromide versus placebo and tiotropium in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD). Method

In clinical practice, no interactions with other COPD medications such as as soon as it reaches the bloodstream, it is considered to have a very low potential for interactions. Data reported as LS mean change from baseline (ANCOVA). Many patients with COPD experience early-morning or nighttime peaks in symptom severity ( ), there is a lack of therapeutic options for their management. Hydrolysis is both non-enzymatic and enzymatic, the latter mainly by The acid metabolite has a plasma protein binding of 87%, and the alcohol of 15%. Only aclidinium produced significant improvements in individual early-morning symptoms of phlegm, shortness of breath, wheeze, and cough compared with placebo at week 6.

Only aclidinium significantly reduced the severity of early-morning cough, wheeze, shortness of breath, and phlegm, and of nighttime symptoms versus placebo (p < 0. Patients received aclidinium 400 μg twice daily (morning and evening), tiotropium 18 μg once daily (morning), or placebo for 6 weeks. This is the first report of this therapeutic effect with a LAMA but should, along with the other COPD additional symptoms findings, be interpreted with some caution given the generally mild symptoms that patients reported at baseline, the small magnitude of the reductions observed, and the as yet unvalidated state of this tool. Correspondence to: Dr Jutta Beier, insaf Respiratory Research Institute, Biebricher Allee 34, 65187, Wiesbaden, Germany, phone: +49, email: This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited. Demographics and baseline characteristics were similar across treatment groups, with the exception of higher proportions of male patients in the aclidinium and tiotropium groups than in the placebo group (Table at screening (adjusted for gender-related differences) was similar in each treatment group but, reflective of the higher proportion of male patients in the active treatment groups, mean FEV was slightly higher in these groups versus the placebo group.

Consequently, the importance of identifying and managing early-morning symptoms is generally accepted. Adverse events (AEs) were recorded throughout the study and assessed for severity and relationship to study treatment by the investigator. Following screening and a 2- to 3-week run-in period, during which disease stability was assessed, patients were randomized (2:2:1) via an interactive voice-response system and computer-generated schedule to receive aclidinium bromide 400 μg (metered dose; equivalent to aclidinium 322 μg delivered dose) BID in the morning and evening via the Genuair®/Pressair multidose dry powder inhaler, tiotropium 18 μg QD in the morning via the HandiHaler®, or placebo for 6 weeks. However, while a second evening dose of aclidinium may be beneficial in terms of improving nighttime and early-morning symptoms under clinical trial conditions, the potential disadvantages of BID versus QD dosing should also be considered. Patients were permitted to continue stable use of oral sustained-release theophylline (use of other methylxanthines was not permitted), inhaled corticosteroids, and oral or parenteral corticosteroids (prednisone ≤10 mg/day or 20 mg/every other day, or equivalent), except ≤6 hours before each visit. Significant improvements in E-RS total scores over 6 weeks were numerically greater with aclidinium (p < 0. Change from baseline in normalized FEV ) at week 6 was the secondary endpoint. COPD medications prior to the start of the study. Change from baseline in E-RS total and domain scores over 6 weeks. The incidence of potentially anticholinergic AEs was similarly low across treatment groups (1 patient in any group.

Aclidinium (Bretaris Genuair) for chronic obstructive pulmonary ...

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